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Acta Pharmaciae Indonesia : Acta Pharm Indo
Published by Universitas Jenderal Soedirman
ISSN : 23378433     EISSN : 26214520     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Journal of Acta Pharmaciae Indonesia is a journal published twice a year by Pharmacy Department, Jenderal Soedirman University, Purwokerto with the Number of ISSN 2337-8433 and E-ISSN 2621-4520. Our journal discusses various pharmaceutical fields in terms of Pharmaceutics & Pharmaceutical Technology, Pharmaceutical Biology, Pharmaceutical Chemistry, and Pharmacology & Clinical Pharmacy.
Arjuna Subject : -
Articles 7 Documents
 1 
Search results for , issue "Vol 8 No 2 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo" : 7 Documents clear
Systematic Review The Effectiveness of Fibrinolytic Therapy in STEMI Patients Anindya Widyasari Ekasuci; Laksmi Maharani; Dewi Latifatul Ilma
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 2 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2020.8.2.3439

Abstract

The use of fibrinolytic as a reperfusion therapy for STEMI patients has many benefits, but in its use, it is not yet decided whether fibrinolytic therapy is an effective therapy for STEMI patients. This study aimeds to evaluate and determine the effectiveness of fibrinolytic therapy for STEMI patients through a systematic review method. The selected articles PubMed and Cochrane that fulfilled the keyword search based on PICO (fibrinolytic or thrombolytic, effectiveness or efficacy), and were uploaded from 2010 to 2020 were included in this study. The searching was conducted from 15 May 2020 untill 27 June 2020. From the total of 525 searches displayed, 17 articles were included in the inclusion criteria. Research showed that fibrinolytic with rescue PCI or as adjunctive therapy is an effective therapy in STEMI patients by increasing myocardial perfusion, epicardial flow, ST segment resolution, TIMI score, peak time to troponin reach, and reduce LVEF risk. Fibrinolytic therapy with rescue PCI or as adjunctive therapy is also effective in reducing infarct size and the risk of cardiogenic shock. Fibrinolytic as pharmacoinvasive therapy is an effective therapy for patients with a diagnosis of STEMI.
Antioxidant Activity and Total Flavonoid Content of Zingiber aromaticum Val. Sunarto Sunarto; Nur Amalia Choironi; Faridah Laeli Syarifah
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 2 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2020.8.2.3517

Abstract

Increase prevalence of degenerative disease caused by free radicals. Zingiber aromaticum is known to be used as traditional medicine. The purpose of this study was to known antioxidant activity and total flavonoid content of Z. aromaticum from Lembang. The extract was obtained by maceration method using ethanol solvent. Total flavonoid content was carried out using spectrophotometry. The antioxidant activities was carried out by Ferric Reducing Antioxidant Power (FRAP) method. Corellation between total flavonoid content and antioxidant activities using statistic with Pearson’s Correlation method. The results shown that antioxidant activities of Z. aromaticum is weak with total flavonoid content is 9,924 ± 0,544 mg quercetin/ g extract.
Antibacterial and Toxicity Activity from Non Polar Fraction of Gal Manjakani (Quercus infectoria) iin asparinda; Tita Juwitaningsih
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 2 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2020.8.2.3487

Abstract

Gal manjakani (Quercus infectoria) is one of the most popular medicinal plants in Asia. This plant is found in Turkey, Syria, Persia, Cyprus, and Greece. This study aims to determine the compounds contained in the non-polar fraction and to determine the antibacterial activity and toxicity of the fraction. Gal Manjakani was extracted by maceration method with acetone then fractionated with n-hexane, ethyl acetate and methanol. Non-polar fractions were analyzed using Gas Chromatography-Mass Spectroscopy (GCMS). The antibacterial activity test used disc diffusion and microdilution methods based on the CLSI standard method against Staphylococcus aureus and Escherichia coli bacteria. Toxicity test was conducted using the Brine Shrimp Lethality Test (BSLT) method. The GC-MS identification results showed that the non-polar fraction of gal manjakani contained 27 compounds, with the main compounds being cis-vaccenic acid = 35,19%, n-hexadecanoic acid = 16,66%, 1-heptadecanecarboxylic acid = 5,03%, dodecanoic acid = 4.73%, bis (2-ethylhexyl) phthalate = 4,35%, hexadecanoic acid, methyl ester = 2,14% and tetradecanoic acid = 1,31%. The results of the antibacterial activity test showed activity with an inhibition zone of 6.26 ± 0.6 mm against S.aureus bacteria and 8.23 ​​± 0.21 mm against E.coli bacteria, with a percentage of effectiveness against S.aureus bacteria of 15.34% and for E. coli 44.24%. The MIC and MBC values ​​of S.aureus bacteria were> 5000 (µg / mL) and> 5000 (µg / mL) and E. coli was 312.5 (µg / mL) and> 5000 (µg / mL). The results of the toxicity test showed that the non-polar fraction of gal Manjakani was toxic with an LC50 value of 2.1527 ppm.
Cholesterol Profile in The Dyslipidemia Patient Related to Pill Taking Time at Primary Healthcare in Purwokerto Ika Mustikaningtias; Hening Pratiwi; Laksmi Maharani
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 2 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2020.8.2.2432

Abstract

Dyslipidemia is a lipid metabolism disorder in Indonesians aged >15 years old. Pharmacokinetics and pharmacodynamics of Statin, the drug of choice for dyslipidemia, are influenced by circadian rhytms and thus require timing of pill taking time. The aims of this study are to determine relationship between the respondent characteristics to blood ccholesterol level and the effect of taking Simvastatin in the afternoon on the cholesterol level’s profile. The results showed that only body mass index (BMI) had an effect on cholesterol level (p=0,016) with Pearson correlation -0,685 (p=0,029). The cholesterol level is lower in respondents whose BMI is not ideal. The difference of pill taking time, at 18.00-21.00 and 21.00-24.00, did not show a difference profile of cholesterol level during one month of therapy. This results indicate that Simvastatin can be taken in the time range 18.00-24.00 to control cholesterol level of dyslipidemia patients.
Hepatoprotective Activity of Ethanolic Extract of Sida rhombifolia L. Leaf in CCl4-induced Rats Nisa Isneni Hanifa; Wahyu Widyaningsih
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 2 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2020.8.2.2929

Abstract

Streptococcus mutans is responsible for cause the dental caries. The purpose of this research was to test antibacterial activity of Ganitrus leaves. The bacterial activity of methanol and aquadest by disc difusion method with 10%; 20%; 30%; 40%; 50% and 100%. The extracts showed that methanol extract had activity with susceptible category at concentration of 10%, 30%, 50% and 100% against Streptococcus mutans with inhibition zone 15.74mm, 16.68 mm, 16.70 mm and 17.68 mm, respectively. Aquadest extract showed activity with intermediet category of 30% and 100% with inhibition zone 11,04 mm and 11,39 mm. The methanol extract showed that activity of antibacterial better than the aqueous Elaeocarpus ganitrus Roxb leaves.
Uji Aktivitas Antibakteri Ekstrak Metanol dan Akuades Daun Ganitri (Elaeocarpus ganitrus Roxb.) Terhadap Bakteri Streptococcus mutans Naelaz Zukhruf Wakhidatul Kiromah; Wahyu Rahmatulloh
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 2 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2020.8.2.3237

Abstract

Streptococcus mutans is responsible for cause the dental caries. The purpose of this research was to test antibacterial activity of Ganitrus leaves. The bacterial activity of methanol and aquadest by disc difusion method with 10; 20; 30; 40; 50 and 100%. The extracts showed that methanol extract had activity with category susceptible at concentration of 50% and 100% against Streptococcus mutans with inhibition zone 16,70 and 17,68 mm respectively. Aquadest extract showed activity with category intermediet of 30% and 100% with inhibition zone 11,04 and 11,39 mm. There is a significant difference in the inhibition zone diameter at each treatment.
Effect of Ethanol Extract of Green Tea (Camellia Sinensis) to Lowering Iron Level in Ferrous Sulfate Induced Male Rats Hendri Wasito; Hanif Nasiatul Baroroh; Yossi Respa Sandiani
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 8 No 2 (2020): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2020.8.2.3226

Abstract

Green tea (Camellia sinensis) has the potential to be developed as a natural agent for therapy of iron overload in thalassemia. The purpose of this research was to observe the ability of ethanol extract of green tea as a natural iron chelating agent in animal iron overload model. Ethanol extract of green tea leave (GTLE) was prepared by maceration using 70% ethanol. Sprague-Dawley male rats were divided into three groups (5 rats each), a normal control group (group I) received daily p.o. of deionized water, the iron overload group received 100 g/Kg BW (group II) of GTLE that given two hours before ferroussulfate0.5 g/Kg BW administrations and the last group (group III) received only 0.5 g/Kg BW of ferrous sulfate. GTLE and ferrous sulfate were given orally every day for 30 days. At the end of the experimental period, rat blood serum samples were collected. Iron content and alanine aminotransferase (ALT) levels were measured using a spectrophotometer followed by observing the histologic preparation of rat liver organ. The results showed that administration of green tea leaves ethanolic extract of 100 g/Kg BW was able to keep down iron and ALT levels in the rat blood to a normal level.

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